Applying to positions where you don’t meet the minimum experience?

How serious are companies about enforcing the "required years of experience" on job listings? I am a B4 auditor wanting to make the jump to industry. I am a CPA, but there are tons of listings for staff/senior accountants that require 3-5 years of experience, which seems ridiculous to me. If i send them a resume with 2 year B4 audit experence with a CPA and a masters in accounting, are they just going to trash it?