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How do I give notice at a Big 4 firm?

Far be it from me to work on a weekend, but it sounds like this guy, who emailed us and wants to go by IWantOut, is desperate for some guidance:

How do I give notice at a Big 4 firm? I'm still on probation and I want out. I'm not in accounting, I'm in IT audit. It'll be pretty easy to find another job. I'm not too worried. I see adverts looking for graduate programmers all the time. Ill probably use the money I made here to do some traveling first.

Anyway, I'm just a newbie and don't know how to do this. Do I contact HR? Do I tell my manager first? Do I email the director of my business unit who I supposedly "report to" but barely ever see? Will I have to sit in a meeting with him/her and explain myself? Please respond asap because my probation is nearly up, and I'd rather give my notice before its finished.

Just a reminder — The fastest way to get answers to your questions around here is to post it here on Open Items. All you have to sign up here and you can post to your heart's content.